Transgenic Animals PPT: Definition, Examples, Applications, Advantages

Transgenic Animals PPT: Definition, Examples, Applications, Advantages

Definition of Transgenic Animals:

Animals (most typically mice) that have had a foreign gene purposely put into their genome are known as transgenic animals. The most common procedure for creating such animals is the microinjection of DNA into the pronuclei of a fertilized egg, which is then implanted into the oviduct of a pseudopregnant surrogate mother. As a result, the receiving animal gives birth to genetically changed pups.

Applications of Transgenic Animals:

  1. As disease model: Disease models (animals genetically modified to exhibit disease symptoms so that effective treatments can be researched) such as Alzheimer’s, tumors, and AIDS are created using transgenic animals. Scientists can better grasp the role of genes in specific diseases by using transgenic animals.
  2. Biological Products: Transgenic animals are utilized to manufacture proteins such as alpha-1-antitrypsin, which is produced in the liver and is used to treat emphysema and cystic fibrosis.
  3. Xenotransplantation: By deleting the gene responsible for the human fast immunological rejection reaction, genetically modified pigs can be used as a source animal for human tissues and organs for transplantation.
  4. Vaccine testing is done on transgenic animals.

Examples of Transgenic Animals:

  1. Dolly sheep:

The first cloned mammal from an adult cell was Dolly, the sheep. The nucleus of an unfertilized egg from a Scottish Blackface ewe was extracted and the udder cells of a 6-year-old Finn Dorset white sheep were introduced into it. After fusion, it was subsequently put into a second Scottish Blackface ewe, who gave birth to Dolly, the transgenic sheep.

  • Transgenic Mice

Female mice’s oocytes or 1-2 celled embryos are injected with DNA to create transgenic animals. 

Advantages Transgenic Animals:

  1. Nutrients in animal products are being improved, including their amount
  2. Improvement of overall food quality, and specific nutritional content.
  3.  Transgenic technology could allow for the transfer or enhancement of nutritionally advantageous characteristics.

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